Cellular Prion Protein (PrPC) of the Neuron Cell Transformed to a PK-Resistant Protein Under Oxidative Stress, Comprising Main Mitochondrial Damage in Prion Diseases

Novel Proteinaceous Infectious Particles Cause Scrapie

Stanley B. Prusiner · Science · 1982 · 5.1K citations

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Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

Enza Maria Valente, Patrick M. Abou‐Sleiman, Viviana Caputo et al. · Science · 2004 · 3.5K citations · Full text

Life Sciences, Genetics, Molecular Genetics +17

Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation)

Henryk Kozłowski, Anna Janicka-Kłos, Justyna Brasuń et al. · Coordination Chemistry Reviews · 2009 · 469 citations

Life Sciences, Neurobiology, Neuroscience +16

In vitro Conversion of Full-length Mammalian Prion Protein Produces Amyloid Form with Physical Properties of PrPSc

Olga V. Bocharova, Leonid Breydo, Vadim V. Salnikov et al. · Journal of Molecular Biology · 2004 · 250 citations

Life Sciences, Biochemistry, Molecular Biology +15

De novo generation of a PrPSc-like conformation in living cells

Jiyan Ma, Susan Lindquist · Nature Cell Biology · 1999 · 115 citations

Life Sciences, Cell Biology, Molecular Biology +13