Proceedings of the National Academy of Sciences · 2005 · 123 citations · 24 references
Life SciencesCell BiologyMolecular BiologyEnzymologyMolecular Cell BiologyTranscriptional RegulationEnzyme FunctionPhosphoinositide SignalingProtein Kinase CascadesProtein PhosphorylationPhosphatidylinositol 3, 4, 5-Trisphosphate SignalingPhosphatidylinositol 3-Kinase PathwayPhosphatidylinositol 4, 5-BisphosphatePhosphoinositide 3-Kinase PathwayPhosphoinositide 3-Kinase SignalingPhosphoinositide KinasesPhosphoinositide PhosphorylationPi3k Signaling
Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhibited phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.
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