Liquid chromatographic–tandem mass spectrometric assay for the simultaneous quantification of Camptosar® and its metabolite SN-38 in mouse plasma and tissues

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata^1,2

Monroe E. Wall, Mansukh C. Wani, Clarence Cook et al. · Journal of the American Chemical Society · 1966 · 2.2K citations

Medicine, Medicinal Chemistry, Pharmacology +8

Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).

Ron H.J. Mathijssen, R J van Alphen, Jaco J. Verweij et al. · PubMed · 2001 · 752 citations · Full text

Medicine, Oncology, Pharmacology +17

Current perspectives on the clinical experience, pharmacology, and continued development of the camptothecins.

Rocio García‐Carbonero, Jeffrey G. Supko · PubMed · 2002 · 496 citations

Medicine, Oncology, Pharmacology +16

Antitumor activity of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothec in, a novel water-soluble derivative of camptothecin, against murine tumors.

Takehiko Kunimoto, Kazuo Nitta, Takashi Tanaka et al. · PubMed · 1987 · 412 citations

Pharmacy, Medicinal Chemistry, Pharmacology +15