The winged-helix transcription factor HNF-3β is required for notochord development in the mouse embryo

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

En Li, Timothy H. Bestor, Rudolf Jaenisch · Cell · 1992 · 4K citations

Life Sciences, Genetics, Molecular Biology +14

Sonic hedgehog mediates the polarizing activity of the ZPA

Robert D. Riddle, Randy L. Johnson, Ed Laufer et al. · Cell · 1993 · 2.3K citations

Life Sciences, Cell Biology, Developmental Biology +10

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

Yann Echelard, Douglas J. Epstein, Benoit St‐Jacques et al. · Cell · 1993 · 2.2K citations

Life Sciences, Neurobiology, Neuroscience +13

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

Suzanne L. Mansour, Kirk R. Thomas, Mario R. Capecchi · Nature · 1988 · 1.7K citations

Medicine, Genetics, Molecular Genetics +15

Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene

Victor L. J. Tybulewicz, C. Crawford, Peter K. Jackson et al. · Cell · 1991 · 1.3K citations

Medicine, Genetics, Molecular Biology +15