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Effects of Minocycline Plus Tissue Plasminogen Activator Combination Therapy After Focal Embolic Stroke in Type 1 Diabetic Rats

Xiang Fan, Eng H. Lo, Xiaoying Wang

Stroke · 2013 · 71 citations · 30 references

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Abstract

Combination therapy with minocycline plus tPA may be beneficial in ameliorating inflammation and reducing infarction, brain swelling, and hemorrhage after ischemic stroke with diabetes mellitus/hyperglycemia.

References

30

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Role of matrix metalloproteinases in delayed cortical responses after stroke

Bing–Qiao Zhao, Sophia Y. Wang, Hahn-Young Kim et al. · Nature Medicine · 2006 · 686 citations

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Matrix Metalloproteinase-9 Pretreatment Level Predicts Intracranial Hemorrhagic Complications After Thrombolysis in Human Stroke

Joan Montaner, Carlos A. Molina, Jasone Monasterio et al. · Circulation · 2003 · 537 citations

Minocycline treatment in acute stroke

Yair Lampl, Mona Boaz, R. Gilad et al. · Neurology · 2007 · 429 citations

Chronic Treatment With Minocycline Preserves Adult New Neurons and Reduces Functional Impairment After Focal Cerebral Ischemia

Zhengyan Liu, Fan Yang, Seok Joon Won et al. · Stroke · 2006 · 292 citations · Full text