Reduced Adiponectin Signaling Due to Weight Gain Results in Nonalcoholic Steatohepatitis Through Impaired Mitochondrial Biogenesis

Abstract

Lepr(db/db) mice fed a diet high in unsaturated fat develop weight gain and NASH through adiponectin depletion, which is associated with adipose tissue inflammation and hepatic mitochondrial dysfunction. We propose that this murine model of NASH may provide novel insights into the mechanism for development of human NASH.