Local RAS and inflammatory factors are involved in cardiovascular hypertrophy in spontaneously hypertensive rats

Angiotensin-converting enzyme 2 is an essential regulator of heart function

Michael A. Crackower, Renu Sarao, Gavin Y. Oudit et al. · Nature · 2002 · 1.8K citations

Life Sciences, Cardiology, Physiology +10

Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney

Steven D. Crowley, Susan B. Gurley, M Herrera et al. · Proceedings of the National Academy of Sciences · 2006 · 706 citations · Full text

Medicine, Cardiology, Physiology +17

Tumor Necrosis Factor-α Mediates Cardiac Remodeling and Ventricular Dysfunction After Pressure Overload State

Mei Sun, Manyin Chen, Fayez Dawood et al. · Circulation · 2007 · 378 citations · Full text

Life Sciences, Cardiology, Physiology +17

Blood pressure variability is more important than blood pressure level in determination of end-organ damage in rats

Chao‐Yu Miao, He‐Hui Xie, Lin-shu Zhan et al. · Journal of Hypertension · 2006 · 159 citations

Life Sciences, Cardiology, Physiology +17

Synergistic Expression of Angiotensin-Converting Enzyme (ACE) and ACE2 in Human Renal Tissue and Confounding Effects of Hypertension on the ACE to ACE2 Ratio

Shigeyuki Wakahara, Tadashi Konoshita, Shinichi Mizuno et al. · Endocrinology · 2007 · 116 citations · Full text

Life Sciences, Molecular Biology, Nephrology +8