Concepedia

In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y2 receptor

James R. Shoblock, Natalie Welty, Diane Nepomuceno, Brian Lord, Leah Aluisio, Ian Fraser, S. Timothy Motley, Steve W. Sutton, Kirsten L. Morton, Ruggero Galici,

Psychopharmacology · 2009 · 52 citations · 30 references

DOI

Concepts

References

30

The rat brain in stereotaxic coordinates

Miklós Palkovits · Neuropeptides · 1983 · 29K citations

, , +12

Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome

Lydia E. Kuo, Joanna Kitlińska, Jason U. Tilan et al. · Nature Medicine · 2007 · 652 citations

, , +17

Locus coeruleus neurons in the rat containing neuropeptide Y, tyrosine hydroxylase or galanin and their efferent projections to the spinal cord, cerebral cortex and hypothalamus

Vicky R. Holets, Tomas Hökfelt, Åke Rökaeus et al. · Neuroscience · 1988 · 370 citations

, , +17

BIIE0246: A selective and high affinity neuropeptide Y Y2 receptor antagonist

Henri Doods, Wolfram Gaida, H. Wieland et al. · European Journal of Pharmacology · 1999 · 189 citations

, , +14

Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults

Ngozi Erondu, Ira Gantz, Bret J. Musser et al. · Cell Metabolism · 2006 · 184 citations · Full text

, , +13