Cyclooxygenase‐2 Expression in Polyps From a Patient With Juvenile Polyposis Syndrome With Mutant <i>BMPR1A</i>

Abstract

Decreased expression of pSMAD1 in the cystic epithelium with further reduction in the adenomatous area, and increase in COX-2 expression within polyps from the BMPR1A heterozygote, suggest a potential mechanism for adenomatous pathogenesis in these hamartomatous polyps. This may imply that COX-2 inhibitors could be a means for chemoprevention in this syndrome.