The discovery of avanafil for the treatment of erectile dysfunction: A novel pyrimidine-5-carboxamide derivative as a potent and highly selective phosphodiesterase 5 inhibitor

Testosterone Restores Diabetes-Induced Erectile Dysfunction and Sildenafil Responsiveness in Two Distinct Animal Models of Chemical Diabetes

Xinhua Zhang, Sandra Filippi, Annamaria Morelli et al. · The Journal of Sexual Medicine · 2006 · 138 citations

Medicine, Endocrinology, Urology +16

A Randomized, Double-Blind, Placebo-Controlled Evaluation of the Safety and Efficacy of Avanafil in Subjects with Erectile Dysfunction

Irwin Goldstein, Andrew McCullough, LeRoy Jones et al. · The Journal of Sexual Medicine · 2012 · 104 citations

Medicine, Pharmacology, Urology +6

Avanafil, a Potent and Highly Selective Phosphodiesterase-5 Inhibitor for Erectile Dysfunction

Jun Kotera, Hideki Mochida, Hirotaka Inoue et al. · The Journal of Urology · 2012 · 64 citations

Medicine, Pharmacology, Urology +13

Avanafil for the treatment of erectile dysfunction: initial data and clinical key properties

George T. Kedia, Stefan Ückert, Farhang Assadi-Pour et al. · Therapeutic Advances in Urology · 2012 · 49 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +11

Design and synthesis of novel 5-(3,4,5-trimethoxybenzoyl)-4-aminopyrimidine derivatives as potent and selective phosphodiesterase 5 inhibitors: Scaffold hopping using a pseudo-ring by intramolecular hydrogen bond formation

Toshiaki Sakamoto, Yuichi Koga, Masataka Hikota et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 27 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14