Involvement of CYP2J2 and CYP4F12 in the Metabolism of Ebastine in Human Intestinal Microsomes

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism*

Kenneth E. Thummel, Diarmuid O’Shea, Mary F. Paine et al. · Clinical Pharmacology & Therapeutics · 1996 · 619 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Molecular Cloning and Expression of CYP2J2, a Human Cytochrome P450 Arachidonic Acid Epoxygenase Highly Expressed in Heart

Shu‐Hsing Wu, Cindy R. Moomaw, Kenneth B. Tomer et al. · Journal of Biological Chemistry · 1996 · 481 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*

Chi-Yuan Wu, Leslie Z. Benet, Mary F. Hébert et al. · Clinical Pharmacology & Therapeutics · 1995 · 356 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: Regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes

Arleen B. Rifkind, Charis A. Lee, Thomas K. H. Chang et al. · Archives of Biochemistry and Biophysics · 1995 · 248 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Oxidation of the antihistaminic drug terfenadine in human liver microsomes. Role of cytochrome P-450 3A(4) in N-dealkylation and C-hydroxylation.

Chul‐Ho Yun, Richard A. Okerholm, F. Peter Guengerich · Drug Metabolism and Disposition · 1993 · 229 citations

Medicine, Medicinal Chemistry, Pharmacology +16