Downregulating sCLU Enhances the Sensitivity of Hepatocellular Carcinoma Cells to Gemcitabine by Activating the Intrinsic Apoptosis Pathway

Clusterin inhibits apoptosis by interacting with activated Bax

Honglai Zhang, Jin Koo Kim, Chris Edwards et al. · Nature Cell Biology · 2005 · 452 citations

Life Sciences, Cancer Biology, Cell Biology +12

Testosterone-repressed prostate message-2 is an antiapoptotic gene involved in progression to androgen independence in prostate cancer.

Hideaki Miyake, Colleen C. Nelson, Paul S. Rennie et al. · PubMed · 2000 · 223 citations · Full text

Life Sciences, Endocrinology, Oncology +17

Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis

Guang Zhu, Meenakshi J. Mistry, Cathy Ley-Ebert et al. · Journal of Clinical Investigation · 2000 · 208 citations · Full text

Medicine, Immunology, Pathology +15

Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

Ioannis P. Trougakos, Magda Lourda, Marianna H. Antonelou et al. · Clinical Cancer Research · 2008 · 157 citations

Life Sciences, Cell Biology, Oncology +16

Clusterin plays an important role in hepatocellular carcinoma metastasis

S. H. Lau, Jonathan S. T. Sham, Dan Xie et al. · Oncogene · 2005 · 153 citations

Medicine, Cancer Biology, Oncology +14