LACK OF ADVERSE INFLUENCE OF BLACK PEPPER, ITS OLEORESIN AND PIPERINE IN THE WEANLING RAT

Abstract

ABSTRACT Black pepper, its oleoresin or its active principle piperine fed to rats at doses 5 to 20 times normal human intake did not cause any adverse effect on: (1) growth, food efficiency ratio and organ weights; (2) RBC, WBC and differential counts; (3) the levels of blood constituents like hemoglobin, total serum proteins, albumin, globulin, sugar and cholesterol; (4) the levels of serum aminotransferases and phosphatases and (5) fat and nitrogen balance.