Quinidine: potent inhibition of sparteine and debrisoquine oxidation in vivo.

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

S V Otton, T. Inaba, W. Kalow · Life Sciences · 1984 · 187 citations

Medicine, Medicinal Chemistry, Pharmacology +13

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase.

T. Inaba, M Jurima, W. A. Mahon et al. · Drug Metabolism and Disposition · 1985 · 180 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Single-dose quinidine treatment inhibits metoprolol oxidation in extensive metabolizers

T. Leemann, Pierre Dayer, Urs Meyer · European Journal of Clinical Pharmacology · 1986 · 113 citations

Medicine, Pharmacology, Pharmacotherapy +9

Polymorphic drug oxidation in humans.

Michel Eichelbaum · PubMed · 1984 · 62 citations

Medicine, Genetics, Pharmacology +15

Comparative pharmacogenetics of sparteine and debrisoquine

T. Inaba, Alexander A. Vinks, S V Otton et al. · Clinical Pharmacology & Therapeutics · 1983 · 38 citations

Medicine, Biochemistry, Pharmacology +15