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Immune Response of Congenitally Thymusless Mice to Heterologous Erythrocytes
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1972
Year
ImmunohematologyLymphocyte DevelopmentImmunologyBlood CellReproductive BiologyCongenitally Thymusless MiceEmbryologyHematologyPublic HealthPlaque-forming Cell ResponseCell TransplantationAnimal PhysiologyXenotransplantationAutoimmune DiseaseAutoimmunityNormal Littermate ControlsInborn Error Of ImmunityDevelopmental BiologyHemolysin ProductionAnimal ScienceMedicine
SummaryHemagglutinin and hemolysin production by congenitally thymusless (“nude”) mice in response to intraperitoneal injection of 107, 108, 109, or 1010 sheep erythrocytes (SE) was significantly lower than in normal littermate controls. The plaque-forming cell response of nudes was also impaired. Rosette-forming cells (RFC) were observed in unimmunized nude mice. Injection of SE did not result in the formation of increased numbers of RFC in nude mice, whereas littermate controls responded strongly.The authors express appreciation to R. C. Roberts and D. S. Falconer for providing the breeding nucleus of mice carrying nude and to Mrs. Billie Welty for excellent technical assistance.