Increasing Kaposiʼs sarcoma-associated herpesvirus seroprevalence with age in a highly Kaposiʼs sarcoma endemic region, Zambia in 1985

Abstract

KSHV infection was significantly more common in this region of Zambia in 1985 than it currently is in the United States. Our data are consistent with KSHV being well-established in this region prior to 1985 and that continued adult transmission of the virus was occurring. The high seroprevalence in the adolescent age-group and the relatively linear increase in prevalence with age suggest that non-sexual modes of transmission may be important for KSHV transmission in Africa.