Psychiatry and Clinical Neurosciences · 2001 · 35 citations · 7 references
MedicineNeurologyNutritional SciencesCircadian RhythmsDementiaGeriatric PsychiatryCognitive AgingCognitive HealthCognitive ImpairmentDementia TreatmentVitamin B12 DeficiencyVitamin B12 PhysiologyB VitaminsBright Light ExposureCircadian Rhythm DysregulationCognitive StageCognitive State MonitoringLight-based TherapyMental State ExaminationVigilance
The present study investigated the effects of vitamin B12 (VB12) on circadian rhythm in Alzheimer-type dementia (ATD). Twenty-eight ATD patients were treated with bright light therapy (BLT) for 8 weeks. For the latter 4 weeks, half were treated with VB12 with BLT (BLT + VB12). We evaluated the cognitive state with Mini-Mental State Examination and the circadian rhythm with actigraphy after the fourth and eighth week. After the first 4 weeks BLT improved the circadian rhythm disturbances and cognitive state especially in the early stage of ATD. Although the latter 4 week-BLT caused no significant effects on the circadian rhythm; BLT + VB12 improved the vigilance level during the daytime. These results suggest that VB12 has some efficiency to enhance vigilance for ATD patients.
7
Marshal F. Folstein, Susan E. Folstein, Paul R. McHugh · Journal of Psychiatric Research · 1975 · 86.9K citations
Clinical diagnosis of Alzheimer's disease
Guy M. McKhann, David A. Drachman, Marshall Folstein et al. · Neurology · 1984 · 28K citations · Full text
A New Clinical Scale for the Staging of Dementia
Charles P. Hughes, Leonard van den Berg, Warren L. Danziger et al. · The British Journal of Psychiatry · 1982 · 7K citations