Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance

Gökhan S. Hotamışlıgil, Narinder S. Shargill, Bruce M. Spiegelman

Science

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Peter Arner, J F, Richard L. Atkinson, +1

Journal of Clinical Investigation

Adipose Tissue ExpressionMetabolic DisorderHuman ObesityPathologyAdipokines +17

Protection from obesity-induced insulin resistance in mice lacking TNF-α function

K. Teoman Uysal, Sarah M. Wiesbrock, Michael W. Marino, +1

Nature

ObesityMetabolic SyndromeInflammationInsulin ResistanceInsulin Signaling +12

Leptin Inhibits Bone Formation through a Hypothalamic Relay

Patricia Ducy, Michael Amling, Shu Takeda, +7

Cell

SclerostinPhysiologyHypothalamic PeptideHypothalamic RelayNervous System +4

Leptin Regulates Bone Formation via the Sympathetic Nervous System

Shu Takeda, Florent Elefteriou, Régis Levasseur, +6

Cell

SclerostinSympathetic Nervous SystemPhysiologyHypothalamic PeptideCentral Nervous System +6

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

Jeanne Keffer, Lesley Probert, Haris Cazlaris, +4

The EMBO Journal

InflammationRheumatologyRheumatoid DisorderAutoimmune DiseaseTransgenic Mouse Models +9

TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

Jonathan Lam, Sunao Takeshita, Jane E. Barker, +3

Journal of Clinical Investigation

Impaired On/Off Regulation of TNF Biosynthesis in Mice Lacking TNF AU-Rich Elements

Dimitris L. Kontoyiannis, Manolis Pasparakis, Theresa T. Pizarro, +2

Immunity

InflammationReductive StressKnockout MouseSignal TransductionTnf Biosynthesis +8

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

Philip A. Kern, Mehrnoosh Saghizadeh, Juling Ong, +3

Journal of Clinical Investigation

Metabolic DisorderHuman Adipose TissueImmunologyPathologyTnf Mrna +21

Comprehensive observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse

S. T. Irwin

Psychopharmacology

Quantitative ProcedureNeuropsychologyBehavioral SciencesVeterinary Behavioral MedicineBehavioral Neuroscience +11