Concepedia

Metabolism Studies of Unformulated Internally [3H]-Labeled Short Interfering RNAs in Mice

Jesper Kammersgaard Christensen, Karine Litherland, Thomas Faller, Esther van de Kerkhof, François Natt, Jürg Hunziker, Joel A. Krauser, Piet Swart

Drug Metabolism and Disposition · 2013 · 49 citations · 28 references

DOI

Concepts

References

28

Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

Jennifer A. Lockridge, Lucinda Shaw, Karin S. Blanchard et al. · Nature Biotechnology · 2005 · 1.2K citations

, , +12

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality <i>in vivo</i> imaging

Derek W. Bartlett, Helen C. Su, Isabel J. Hildebrandt et al. · Proceedings of the National Academy of Sciences · 2007 · 797 citations · Full text

, , +17

The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice

Shan Gao, Frederik Dagnæs‐Hansen, Ebbe Juel Bech Nielsen et al. · Molecular Therapy · 2009 · 290 citations · Full text

, , +17

Biodistribution and metabolism of internally 3H-labeled oligonucleotides. I. Comparison of a phosphodiester and a phosphorothioate.

Howard Sands, Lorraine J. Gorey‐Feret, Anthony J. Cocuzza et al. · Molecular Pharmacology · 1994 · 268 citations

, , +15

Biodistribution of phosphodiester and phosphorothioate siRNA

Dwaine A. Braasch, Zain Paroo, Anca Constantinescu et al. · Bioorganic & Medicinal Chemistry Letters · 2004 · 250 citations

, , +6