Concepedia

Three Hypolipidemic Drugs Increase Hepatic Palmitoyl-Coenzyme A Oxidation in the Rat

Paul B. Lazarow

Science · 1977 · 261 citations · 14 references

DOI

Concepts

Abstract

Male rats treated with clofibrate, tibric acid, or Wy-14,643 show an 11- to 18-fold increase in the capacity of their livers to oxidize palmitoyl-coenzyme A. This provides a plausible biochemical mechanism for the action of these hypolipidemic drugs in reducing lipid concentrations in the serum.

References

14

A fatty acyl-CoA oxidizing system in rat liver peroxisomes; enhancement by clofibrate, a hypolipidemic drug.

Paul B. Lazarow, C. De Duve · Proceedings of the National Academy of Sciences · 1976 · 1.1K citations · Full text

, , +17

THE LARGE-SCALE SEPARATION OF PEROXISOMES, MITOCHONDRIA, AND LYSOSOMES FROM THE LIVERS OF RATS INJECTED WITH TRITON WR-1339

Federico Leighton, Brian D. Poole, Henri Beaufay et al. · The Journal of Cell Biology · 1968 · 1.1K citations · Full text

, , +9

NATURE OF THE HEPATOMEGALIC EFFECT PRODUCED BY ETHYL-CHLOROPHENOXY-ISOBUTYRATE IN THE RAT

R. Hess, W. Stäubli · Nature · 1965 · 595 citations

, , +6

Hepatic Peroxisome Proliferation: Induction by Two Novel Compounds Structurally Unrelated to Clofibrate

Janardan K. Reddy, T. P. Krishnakantha · Science · 1975 · 346 citations

, , +12

Modification of Metabolism and Distribution of Lipids by Ethyl Chlorophenoxyisobutyrate

John M. Thorp, W. Stephen Waring · Nature · 1962 · 340 citations

, , +7