Stereochemical Control of Both C−C and C−N Axial Chirality in the Synthesis of Chiral <i>N</i>,<i>O-</i>Biaryls

Abstract

A Rh(I)-catalyzed asymmetric [2 + 2 + 2] cycloaddition of achiral ynamides is described here. This work demonstrates a unique concept of stereochemical control of both the C-C and C-N axial chirality and provides an approach to the synthesis of chiral N,O-biaryls as well as chiral anilides.