Novel mechanisms of DNA topoisomerase II inhibition by pyranonaphthoquinone derivatives—eleutherin, α lapachone, and β lapachone∗

Structure and mechanism of DNA topoisomerase II

James M. Berger, S.J. Gamblin, Stephen C. Harrison et al. · Nature · 1996 · 856 citations

Life Sciences, Biochemistry, Molecular Biology +12

Cleavage of DNA by mammalian DNA topoisomerase II.

Leroy F. Liu, Thomas C. Rowe, K M Tewey et al. · Journal of Biological Chemistry · 1983 · 533 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Bioactivation as a Model for Drug Design Bioreductive Alkylation

Harold W. Moore · Science · 1977 · 433 citations

Medicine, Pharmacology, Drug Design +5

Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22.

M Tsai-Pflugfelder, Leroy F. Liu, A A Liu et al. · Proceedings of the National Academy of Sciences · 1988 · 397 citations · Full text

Life Sciences, Genetics, Molecular Biology +10

Antitumor bisdioxopiperazines inhibit yeast DNAtopoisomerase II by trapping the enzyme in the form of a closed proteinclamp.

Joaquím Roca, Ryoji Ishida, James M. Berger et al. · Proceedings of the National Academy of Sciences · 1994 · 354 citations · Full text

Medicine, Molecular Biology, Pharmacology +12