Concepedia

Phthalazine PDE4 inhibitors. Part 3: The synthesis and in vitro evaluation of derivatives with a hydrogen bond acceptor

Mauro Napoletano, Gabriele Norcini, Franco Pellacini, Francesco Marchini, Gabriele Morazzoni, Raimondo Fattori, Pierpaolo Ferlenga, Lorenzo Pradella

Bioorganic & Medicinal Chemistry Letters · 2002 · 18 citations · 13 references

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Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity

Robert X. Xu, Anne M. Hassell, Dana E. Vanderwall et al. · Science · 2000 · 334 citations

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Stereospecific binding of the antidepressant rolipram to brain protein structures

Herbert H. Schneider, Ralph Schmiechen, Marina Brezinski et al. · European Journal of Pharmacology · 1986 · 236 citations

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Effects of selective phosphodiesterase inhibitors on the polymorphonuclear leukocyte respiratory burst

Christopher Nielson, Robert E. Vestal, Richard J. Heaslip · Journal of Allergy and Clinical Immunology · 1990 · 172 citations · Full text

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1,4-Cyclohexanecarboxylates:  Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

Siegfried B. Christensen, Aimee M. Guider, Cornelia J. Forster et al. · Journal of Medicinal Chemistry · 1998 · 150 citations · Full text

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Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogs

Michael J. Ashton, David Cook, Garry Fenton et al. · Journal of Medicinal Chemistry · 1994 · 112 citations · Full text

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