Enhanced malignant tumorigenesis in Cdk4 transgenic mice

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

Joseph R. Nevins · Science · 1992 · 1.5K citations

Life Sciences, Molecular Biology, Oncology +17

A p16 ^INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma

Thomas Wölfel, Martina Hauer, Jörg Schneider et al. · Science · 1995 · 1.1K citations

Medicine, Immunology, Oncology +17

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma

Lin Zuo, John Weger, Qingbei Yang et al. · Nature Genetics · 1996 · 811 citations

Life Sciences, Genetics, Molecular Genetics +14

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

Sushil G. Rane, Pierre Dubus, Richard V. Mettus et al. · Nature Genetics · 1999 · 699 citations

Life Sciences, Cell Biology, Molecular Biology +17

CDKN2 (p16/MTS1) gene deletion or CDK4 amplification occurs in the majority of glioblastomas.

Esther Schmidt, Koichi Ichimura, Guido Reifenberger et al. · PubMed · 1994 · 442 citations

Medicine, Genetics, Oncology +14