Involvement of an ICE-like protease in Fas-mediated apoptosis

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

Naoto Itoh, Shin Yonehara, Ai Ishii et al. · Cell · 1991 · 2.8K citations

Molecular Immunology, Apoptosis, Immunology +9

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

Yuri Lazebnik, Scott H. Kaufmann, Serge Desnoyers et al. · Nature · 1994 · 2.6K citations

Protein Chemistry, Biochemistry, Viral Polymerase Structure +6

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Nancy A. Thornberry, Herbert G. Bull, Jimmy Calaycay et al. · Nature · 1992 · 2.6K citations

Inflammation, Cytokine, Granulocyte +6

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

Takashi Suda, Tomohiro Takahashi, Pierre Golstein et al. · Cell · 1993 · 2.5K citations

Inflammation, Signal Transduction, Disease Mechanism +10

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

Cell · 1993 · 2.5K citations · Full text

Cytokine, Signaling Pathway, Cell Regulation +11