Short-term effect of buformin, a biguanide, on insulin sensitivity, soluble fraction of tumor necrosis factor receptor and serum lipids in overweight patients with type 2 diabetes mellitus

Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

William T. Friedewald, Robert I. Levy, Donald S. Fredrickson · Clinical Chemistry · 1972 · 32.5K citations

Life Sciences, Biochemistry, Clinical Biochemistry +14

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance.

Peter Arner, J F, Richard L. Atkinson et al. · Journal of Clinical Investigation · 1995 · 3.5K citations · Full text

Life Sciences, Molecular Biology, Physiology +16

The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase.

Philip A. Kern, Mehrnoosh Saghizadeh, Juling Ong et al. · Journal of Clinical Investigation · 1995 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Physiology +10

Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus.

Ralph A. DeFronzo, Rebeqa Gunnarsson, Ola Björkman et al. · Journal of Clinical Investigation · 1985 · 1.2K citations · Full text

Medicine, Endocrinology, Diabetology +12

Metformin reverses fatty liver disease in obese, leptin-deficient mice

Hui Lin, Shi Qi Yang, Christine Chuckaree et al. · Nature Medicine · 2000 · 679 citations

Medicine, Endocrinology, Pharmacology +14