Journal of the American Chemical Society · 1981 · 204 citations · 0 references
PharmacyMedicinal ChemistryPharmacologyCombinatorial ChemistryDrug DiscoverySynthetic Medicinal ChemistryChemoenzymatic SynthesisRetrosynthetic AnalysisAsymmetric SynthesisNatural Product Total SynthesisTotal Synthesis-derived Analogues
In the preceding paper' we described the preparation of the \nkey lactone intermediate la in optically active form. In this paper we report the synthesis of erythromycin (2) from la. In essence,this transformation involves the glycosidation of a suitable derivative of la with L-cladinose and D-desosamine and the generation of the C-9 ketone functionality.