Oligomerization and Toxicity of β-Amyloid-42 Implicated in Alzheimer's Disease

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

Joseph T. Jarrett, Elizabeth P. Berger, Peter T. Lansbury · Biochemistry · 1993 · 2K citations

Life Sciences, Biochemistry, Molecular Biology +17

Huntingtin Acts in the Nucleus to Induce Apoptosis but Death Does Not Correlate with the Formation of Intranuclear Inclusions

Frédéric Saudou, Steven Finkbeiner, Didier Devys et al. · Cell · 1998 · 1.6K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and therapy

Kelly A. Conway, Seung‐Jae Lee, Jean‐Christophe Rochet et al. · Proceedings of the National Academy of Sciences · 2000 · 1.5K citations

Life Sciences, Neurobiology, Neuroscience +17

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

Dean M. Hartley, Dominic M. Walsh, C P Ye et al. · PubMed · 1999 · 921 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

Dean M. Hartley, Dominic M. Walsh, Chianping P. Ye et al. · Journal of Neuroscience · 1999 · 812 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17