Concepedia

Exploration of liquid and supercritical fluid chromatographic chiral separation and purification of Nutlin-3—A small molecule antagonist of MDM2

Zhen-Yu Wang, Malgorzata Jonca, Ted Lambros, Stephen B. Ferguson, Robert A. Goodnow

Journal of Pharmaceutical and Biomedical Analysis · 2007 · 35 citations · 8 references

DOI

Concepts

References

8

Surfing the p53 network

Bert Vogelstein, David P. Lane, Arnold J. Levine · Nature · 2000 · 6.6K citations

, , +6

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Lyubomir T. Vassilev, Binh Thanh Vu, Bradford Graves et al. · Science · 2004 · 4.7K citations

, , +15

Mdm2 promotes the rapid degradation of p53

Ygal Haupt, Ruth Maya, Anat Kazaz et al. · Nature · 1997 · 4.5K citations

, , +10

Regulation of p53 stability by Mdm2

Michael H.G. Kubbutat, Stephen N. Jones, Karen H. Vousden · Nature · 1997 · 3.3K citations

, , +10

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

, , +10