Antidepressant-Like Effects of κ-Opioid Receptor Antagonists in the Forced Swim Test in Rats

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.

G. Di Chiara, Assunta Impérato · Proceedings of the National Academy of Sciences · 1988 · 4.7K citations · Full text

Medicine, Neuroscience, Pharmacology +17

Depression: a new animal model sensitive to antidepressant treatments

Roger D. Porsolt, Manuel Pichon, M Jalfre · Nature · 1977 · 4.4K citations

Medicine, Neuroscience, Psychiatry +12

Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants

Michael J. Detke, Michael R. Rickels, Irwin Lucki · Psychopharmacology · 1995 · 1.4K citations

Medicine, Neuroscience, Pharmacology +14

Neuroleptics and operant behavior: The anhedonia hypothesis

Roy A. Wise · Behavioral and Brain Sciences · 1982 · 1K citations

Public Health, Behavioral Sciences, Psychology +12

Psychotomimesis Mediated by κ Opiate Receptors

Andreas Pfeiffer, Victor Brantl, Albert Herz et al. · Science · 1986 · 858 citations

Medicine, Behavioral Sciences, Pharmacology +16