Concepedia

Association studies of multiple candidate genes for Parkinson's disease using single nucleotide polymorphisms

Yoshio Momose, Miho Murata, Kazuhiro Kobayashi, Masaji Tachikawa, Yuko Nakabayashi, Ichiro Kanazawa, Tatsushi Toda

Annals of Neurology · 2001 · 197 citations · 17 references

DOI

Abstract

We studied 20 single nucleotide polymorphisms in 18 candidate genes for association with Parkinson's disease. We found that homozygosity for the V66M polymorphism of the brain-derived neurotrophic factor (BDNF) gene occurs more frequently in patients with Parkinson's disease than in unaffected controls (chi(2) = 5.46) and confirmed an association with the S18Y polymorphism of the UCH-L1 gene. Our results provide genetic evidence supporting a role for BDNF in the pathogenesis of Parkinson's disease.

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