Concepedia

Japanese Medaka: A Non-Mammalian Vertebrate Model for Studying Sex and Age-Related Bone Metabolism In Vivo

Shanthanagouda Admane Holeyappa, Baosheng Guo, Rui R. Ye, Chao Liang, Michael Chiang, Singaram Gopalakrishnan, Napo K. M. Cheung, Ge Zhang, Doris W.T. Au

PLoS ONE · 2014 · 33 citations · 30 references

DOIFull text

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Abstract

We demonstrate osteoporosis development associated with natural drop in estrogen level during aging in female medaka, which could be attenuated by estrogen treatment. This small size fish is a unique alternative non-mammalian vertebrate model for studying estrogen-related molecular regulation in postmenopausal skeletal disorders in vivo without ovariectomy.

References

30

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

A. M. Parfitt, Marc K. Drezner, Francis H. Glorieux et al. · Journal of Bone and Mineral Research · 1987 · 5K citations

, , +20

Bone Histomorphometry : Standardization of Nomenclature, Symbols, and Units

A. M. Parfitt, M. K. Drezner, Francis H. Glorieux et al. · Journal of Bone and Mineral Research · 1987 · 3.3K citations

, , +6

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

Ji Li, Ildiko Sarosi, Xiaoqiang Yan et al. · Proceedings of the National Academy of Sciences · 2000 · 1.1K citations · Full text

Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts

Takashi Nakamura, Yuuki Imai, Takahiro Μatsumoto et al. · Cell · 2007 · 980 citations · Full text

, , +11

Relationship of Serum Sex Steroid Levels and Bone Turnover Markers with Bone Mineral Density in Men and Women: A Key Role for Bioavailable Estrogen1

Sundeep Khosla, L. Joseph Melton, Elizabeth J. Atkinson et al. · The Journal of Clinical Endocrinology & Metabolism · 1998 · 927 citations · Full text