Concepedia

The prognostic significance of p53 andbcl-2 expression in lung adenocarcinoma and its correlation with ki-67 growth fraction

Hironori Ishida, Koji Irie, Tsuyoshi Itoh, T Furukawa, Osamu Tokunaga

Cancer · 1997 · 100 citations · 43 references

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Abstract

The results of this study indicated an inverse relationship between the proliferative activity of p53 and bcl-2. Expression of p53 was an independent factor associated with poor prognosis, whereas bcl-2 expression was associated with favorable prognosis.

References

43

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

David M. Hockenbery, Gabriel Núñez, Curt Milliman et al. · Nature · 1990 · 3.8K citations

, , +8

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

Marc S. Greenblatt, W P Bennett, Monica Hollstein et al. · PubMed · 1994 · 3.5K citations

, , +9

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

, , +9

p53: A Frequent Target for Genetic Abnormalities in Lung Cancer

Takashi Takahashi, Marion M. Nau, Itsuo Chiba et al. · Science · 1989 · 1.2K citations

, , +14

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

Timothy J. McDonnell, Patricia Troncoso, Shawn Brisbay et al. · PubMed · 1992 · 1.1K citations

, , +13