The sensitivity of human tumour cells to quinone bioreductive drugs: What role for DT-diaphorase?

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 55.6K citations

Life Sciences, Cell Biology, Apoptosis +14

Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay.

Jane A. Plumb, Robert Milroy, Stan B. Kaye · PubMed · 1989 · 585 citations

Medicine, Pharmacology, Chemotherapy +12

Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver.

Hans J. Prochaska, Paul Talalay · PubMed · 1988 · 408 citations

Medicine, Biochemistry, Toxicology +16

Metabolism of mitomycin C by DT-diaphorase: role in mitomycin C-induced DNA damage and cytotoxicity in human colon carcinoma cells.

David Siegel, N W Gibson, Peter C. Preusch et al. · PubMed · 1990 · 225 citations

Medicine, Molecular Biology, Oncology +15

Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

Susan R. Keyes, Paula M. Fracasso, David Heimbrook et al. · PubMed · 1984 · 177 citations

Medicine, Biochemistry, Oncology +17