Chronic inhibition of farnesyl pyrophosphate synthase improves endothelial function in spontaneously hypertensive rats

Post-transcriptional Regulation of Endothelial Nitric Oxide Synthase mRNA Stability by Rho GTPase

Ulrich Laufs, James K. Liao · Journal of Biological Chemistry · 1998 · 1K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +13

Cellular and molecular mechanisms of action of bisphosphonates

Michael J. Rogers, Sharon Gordon, Helena L. Benford et al. · Cancer · 2000 · 712 citations · Full text

Medicine, Cell Biology, Molecular Biology +12

Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation <i>in vitro</i>

John Fisher, Michael J. Rogers, J. M. Halasy et al. · Proceedings of the National Academy of Sciences · 1999 · 679 citations

Medicine, Biochemistry, Pharmacology +17

Rho GTPase/Rho Kinase Negatively Regulates Endothelial Nitric Oxide Synthase Phosphorylation through the Inhibition of Protein Kinase B/Akt in Human Endothelial Cells

Xiu‐Fen Ming, Hema Viswambharan, Christine Barandiér et al. · Molecular and Cellular Biology · 2002 · 403 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Alendronate Is a Specific, Nanomolar Inhibitor of Farnesyl Diphosphate Synthase

James D. Bergstrom, Richard G. Bostedor, P. Masarachia et al. · Archives of Biochemistry and Biophysics · 2000 · 401 citations

Medicine, Medicinal Chemistry, Pharmacology +7