Advanced Synthesis & Catalysis · 2008 · 119 citations · 65 references
DerivativesEngineeringBiochemistryIndole DerivativesNatural SciencesOrganic ChemistryCatalysisEthyl 3,3,3‐TrifluoropyruvateChemistrySynthetic ChemistryHigh EnantioselectivityAsymmetric Catalysis‐Achiral Acid CombinationEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
Abstract Enantioselective Friedel–Crafts alkylations of a variety of indoles with ethyl 3,3,3‐trifluoropyruvate catalyzed by novel chiral m ‐phenylenebis(imidazoline)‐copper(II) complexes or the bis(imidazoline)‐achiral acid combination afforded products with high enantioselectivity. Both enantiomers of indole derivatives can be prepared with high enantioselectivities by tuning the N‐substituents of the imidazoline.
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