Journal of the American Chemical Society · 2007 · 406 citations · 1 references
Natural SciencesChemistryMedicinal ChemistryCatalysisCatalyst PreparationCatalyst SynthesisCatalytic MechanismsChiral SeparationEnantioselective CatalysisEnantioselective SynthesisIndole ChemistryIndole DerivativesIndole Synthesis
Highly enantioselective Friedel−Crafts reactions of indoles with imines catalyzed by a chiral phosphoric acid are developed, affording the 3-indolyl methanamine derivatives with up to >99% ee for a wide range of substrates.
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