Leptin potentiates the anti-obesity effects of rimonabant

Prevalence and Trends in Obesity Among US Adults, 1999-2000

Katherine M. Flegal · JAMA · 2002 · 6.2K citations

Public Health, Population Health Sciences, Public Health Nutrition +8

AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus

Yasuhiko Minokoshi, Thierry Alquier, Noboru Furukawa et al. · Nature · 2004 · 1.6K citations

Life Sciences, Neuroscience, Physiology +14

Leptin-regulated endocannabinoids are involved in maintaining food intake

Vincenzo Di Marzo, Sravan K. Goparaju, Lei Wang et al. · Nature · 2001 · 1.6K citations

Life Sciences, Endocrinology, Nutritional Sciences +12

The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis

Daniela Cota, Giovanni Marsicano, Matthias H. Tschöp et al. · Journal of Clinical Investigation · 2003 · 1.1K citations · Full text

Life Sciences, Neuroscience, Pharmacology +16

Leptin Directly Activates SF1 Neurons in the VMH, and This Action by Leptin Is Required for Normal Body-Weight Homeostasis

Harveen Dhillon, Jeffrey M. Zigman, Chianping Ye et al. · Neuron · 2006 · 791 citations · Full text

Life Sciences, Neuroscience, Physiology +13