The International Journal of Tuberculosis and Lung Disease · 2015 · 21 citations · 6 references
Veterinary MedicineInfectious DiseasesPharmacologyAntimicrobial ResistanceChemotherapyDiagnostic MicrobiologyAntibiotic ResistanceAntimicrobial Susceptibility TestingMultidrug ResistanceTuberculosis CareTuberculosis DiagnosisTuberculosis Diagnostic TestingCritical ConcentrationDrug Resistance TestingDrug Susceptibility AssaysMultidrug-resistant OrganismsMultidrug-resistant Tuberculosis TreatmentPhenotypic Drug Susceptibility TestingTuberculosis Drug ResistanceTuberculosis Treatment Regimens
Fluoroquinolone (FQ) drug susceptibility testing (DST) is an important step in the design of effective treatment regimens for multidrug-resistant tuberculosis. Here we compare ciprofloxacin, ofloxacin and moxifloxacin (MFX) resistance results from 226 multidrug-resistant samples. The low level of concordance observed suggests that DST should be performed for the specific FQ planned for clinical use. The results also support the new World Health Organization recommendation for testing MFX at a critical concentration of 2.0 μg/ml.
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Frederick A. Sirgel, Robin M. Warren, Elizabeth M. Streicher et al. · Journal of Antimicrobial Chemotherapy · 2012 · 116 citations · Full text
Aggressive Regimens for Multidrug-Resistant Tuberculosis Decrease All-Cause Mortality
Carole D. Mitnick, Molly F. Franke, Michael Rich et al. · PLoS ONE · 2013 · 65 citations · Full text