Systemic but not renal production of prostacyclin is highly reduced in cyclosporin-treated heart transplant recipientst

A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, Stuart Bunting et al. · Prostaglandins · 1976 · 605 citations

Life Sciences, Biochemistry, Physiology +16

THROMBOEMBOLIC COMPLICATIONS AND HAEMOSTATIC CHANGES IN CYCLOSPORIN-TREATED CADAVERIC KIDNEY ALLOGRAFT RECIPIENTS

Yves Vanrenterghem, L Roels, P. Michielsen et al. · The Lancet · 1985 · 328 citations

Medicine, Nephrology, Surgery +10

CYCLOSPORINE SUPPRESSION OF ENDOTHELIAL PROSTACYCLIN GENERATION

Barbara L. Voss, Karen Hamilton, Eleftheria Samara et al. · Transplantation · 1988 · 104 citations

Medicine, Pharmacology, Biochemical Pharmacology +10

Eight-year results of cyclosporine-treated patients with cardiac transplants

Mark T. Grattan, Carlos E. Moreno-Cabral, Vaughn A. Starnes et al. · Journal of Thoracic and Cardiovascular Surgery · 1990 · 92 citations

Medicine, Cardiology, Pharmacology +15

Increased lipid peroxidation in cyclosporin-treated heart transplant recipients

Yves Chancerelle, M. de Lorgeril, Roseline Viret et al. · The American Journal of Cardiology · 1991 · 50 citations

Medicine, Biochemistry, Pharmacology +14