An efficient and stereoselective synthesis of (3S,4R)-(−)-trans-4-(4′-fluorophenyl)-3-hydroxymethyl-N-methylpiperidine

The absolute configurations and pharmacological activities of the optical isomers of fluoxetine, a selective serotonin-uptake inhibitor

David W. Robertson, Joseph H. Krushinski, R W Fuller et al. · Journal of Medicinal Chemistry · 1988 · 162 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Synthesis of Enantiopure<i>trans</i>-3,4-Disubstituted Piperidines. An Enantiodivergent Synthesis of (+)- and (−)-Paroxetine

Mercedes Amat, Joan Bosch, José Hidalgo et al. · The Journal of Organic Chemistry · 2000 · 136 citations

Pharmacy, Chemistry, Medicinal Chemistry +9

Asymmetric synthesis of (−)-paroxetine using PLE hydrolysis

Marvin S. Yu, I. LANTOS, Zhiqiang Peng et al. · Tetrahedron Letters · 2000 · 113 citations

Pharmacy, Chemistry, Medicinal Chemistry +9

Highly Diastereoselective and Enantioselective Carbon−Carbon Bond Formations in Conjugate Additions of Lithiated <i>N</i>-Boc Allylamines to Nitroalkenes:  Enantioselective Synthesis of 3,4- and 3,4,5-Substituted Piperidines Including (−)-Paroxetine

Timothy A. Johnson, Peter Beak · Journal of the American Chemical Society · 2001 · 111 citations

Natural Sciences, Chemistry, Medicinal Chemistry +10

Asymmetric syntheses of trans-3,4-disubstituted 2-piperidinones and piperidines

Lee Tai Liu, Pao‐Chiung Hong, Hsiang‐Ling Huang et al. · Tetrahedron Asymmetry · 2001 · 54 citations

Natural Sciences, Chemistry, Medicinal Chemistry +11