An efficient one‐pot synthesis of <i>N</i>‐(1,3‐diphenyl‐1<i>H</i>‐pyrazol‐ 5‐yl)amides

Abstract

Abstract magnified image A “one‐pot” method for the synthesis of N ‐(1,3‐diphenyl‐1 H ‐pyrazol‐5‐yl)amides was developed by cyclization of benzoylacetonitrile ( 1 ) and phenylhydrazine in neat condition followed by acylation. The corresponding N ‐(1,3‐diphenyl‐1 H ‐pyrazol‐5‐yl)amides were provided in good to excellent yields (70–90%). The significant advantages of the new synthetic method are excellent yields and simple work‐up procedure without isolation and purification of intermediary 5‐amino‐1,3‐diphenyl pyrazol ( 2 ). J. Heterocyclic Chem., (2010).