FTO T/A and Peroxisome Proliferator-Activated Receptor-γ Pro12Ala Polymorphisms but Not ApoA1 −75 Are Associated with Better Response to Lifestyle Intervention in Brazilians at High Cardiometabolic Risk

Abstract

In Brazilian individuals, the FTO T/A polymorphism induces a favorable impact on inflammatory status and glucose metabolism. The reference genotype of PPARγ Pro12Ala seems to favor a better lipid profile, while the variant allele decreases blood pressure. Our data did not support benefits of the variant allele of ApoA1 -75G/A polymorphism. Further studies are needed to direct lifestyle intervention to subsets of individuals at cardiometabolic risk.