Hydralazine-induced promoter demethylation enhances sarcoplasmic reticulum Ca2+-ATPase and calcium homeostasis in cardiac myocytes

S-Glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide

Takeshi Adachi, Robert M. Weisbrod, David R. Pimentel et al. · Nature Medicine · 2004 · 648 citations

Life Sciences, Biochemistry, Physiology +10

Alterations of Sarcoplasmic Reticulum Proteins in Failing Human Dilated Cardiomyopathy

Markus Meyer, Wolfgang Schillinger, Burkert Pieske et al. · Circulation · 1995 · 536 citations

Medicine, Biochemistry, Cardiology +17

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.

Elizabeth Cornacchia, Joseph Golbus, Jonathan Maybaum et al. · The Journal of Immunology · 1988 · 422 citations · Full text

Medicine, Immunology, Pharmacology +10

Reversal of Cardiac Dysfunction After Long-Term Expression of SERCA2a by Gene Transfer in a Pre-Clinical Model of Heart Failure

Yoshiaki Kawase, Hung Q. Ly, Fabrice Prunier et al. · Journal of the American College of Cardiology · 2008 · 340 citations

Life Sciences, Cardiology, Molecular Biology +11

Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase. A new action for an old drug.

Thomas Münzel, Stephan Kurz, Sanjay Rajagopalan et al. · Journal of Clinical Investigation · 1996 · 312 citations · Full text

Medicine, Pharmacology, Physiology +14