Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.

Elizabeth Cornacchia, Joseph Golbus, Jonathan Maybaum, +3

The Journal of Immunology

Epigenetic ChangeDna MethylationImmunologyT CellsEpigenetics +15

Mechanism of Radiosensitization by the Chk1/2 Inhibitor AZD7762 Involves Abrogation of the G2 Checkpoint and Inhibition of Homologous Recombinational DNA Repair

Meredith A. Morgan, Leslie A. Parsels, Lili Zhao, +12

Cancer Research

Dna DamageMedian TimeMolecular BiologyPathologyTumor Biology +15

Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma.

Mukund Dole, Gabriel Núñez, Audrea K. Merchant, +4

PubMed

Hematological MalignancyVector-transfected ControlsBcl-2 Expression VectorGliomaOncogenic Agent +12

Dose Escalation Trial of the Wee1 Inhibitor Adavosertib (AZD1775) in Combination With Gemcitabine and Radiation for Patients With Locally Advanced Pancreatic Cancer

Kyle C. Cuneo, Meredith A. Morgan, Vaibhav Sahai, +10

Journal of Clinical Oncology

Combined Inhibition of Wee1 and PARP1/2 for Radiosensitization in Pancreatic Cancer

David Karnak, Carl G. Engelke, Leslie A. Parsels, +9

Clinical Cancer Research

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

Leslie A. Parsels, Meredith A. Morgan, Daria M. Tanska, +8

Molecular Cancer Therapeutics

PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors

Leslie A. Parsels, David Karnak, Joshua D. Parsels, +8

Molecular Cancer Research

The Combination of Epidermal Growth Factor Receptor Inhibitors with Gemcitabine and Radiation in Pancreatic Cancer

Meredith A. Morgan, Leslie A. Parsels, L.E. Kollar, +3

Clinical Cancer Research

Role of Checkpoint Kinase 1 in Preventing Premature Mitosis in Response to Gemcitabine

Meredith A. Morgan, Leslie A. Parsels, Joshua D. Parsels, +3

Cancer Research

MitophagyCell DeathCell CycleCancer BiologyTumor Biology +15

Inhibition of Protein Phosphatase 2A Radiosensitizes Pancreatic Cancers by Modulating CDC25C/CDK1 and Homologous Recombination Repair

Dongping Wei, Leslie A. Parsels, David Karnak, +8

Clinical Cancer Research