Synthesis and biological evaluations of new analogs of 2-methoxyestradiol: Inhibitors of tubulin and angiogenesis

Protection of hydroxyl groups as tert-butyldimethylsilyl derivatives

E. J. Corey, A. Venkateswarlu · Journal of the American Chemical Society · 1972 · 1.8K citations

Natural Sciences, Chemistry, Analytical Chemistry +6

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

Michael K. Jones, Hongtao Wang, B. M. Peskar et al. · Nature Medicine · 1999 · 826 citations

Medicine, Oncology, Pharmacology +16

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

Theodore Fotsis, Youming Zhang, Michael S. Pepper et al. · Nature · 1994 · 742 citations

Medicine, Oncology, Pharmacology +12

2-Methoxyestradiol, an endogenous mammalian metabolite, inhibits tubulin polymerization by interacting at the colchicine site.

Robert J. D’Amato, C. Michael Lin, Evelyn Flynn et al. · Proceedings of the National Academy of Sciences · 1994 · 409 citations

Life Sciences, Chemical Biology, Pharmacology +16

Cortistatins A, B, C, and D, Anti-angiogenic Steroidal Alkaloids, from the Marine Sponge <i>Corticium simplex</i>

Shunji Aoki, Yasuo Watanabe, Mami Sanagawa et al. · Journal of the American Chemical Society · 2006 · 286 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17