Titanium-promoted highly stereoselective synthesis of α,α-difluoro-β,γ-dihydroxyester. Simple route to 2-deoxy-2,2-difluororibose

Torsional strain involving partial bonds. The stereochemistry of the lithium aluminium hydride reduction of some simple open-chain ketones

M. CHEREST, Hugh Felkin, Nicole Prudent · Tetrahedron Letters · 1968 · 888 citations

Natural Sciences, Chemistry, Organic Chemistry +6

Evaluation of the antitumor activity of gemcitabine (2',2'-difluoro-2'-deoxycytidine).

Larry W. Hertel, G B Boder, Julian S. Kroin et al. · PubMed · 1990 · 683 citations

Medicine, Oncology, Pharmacology +11

Nucleosides. 110. Synthesis and antiherpes virus activity of some 2'-fluoro-2'-deoxyarabinofuranosylpyrimidine nucleosides

Kyoichi A. Watanabe, U. REICHMAN, Kosaku Hirota et al. · Journal of Medicinal Chemistry · 1979 · 268 citations

Life Sciences, Chemistry, Medicinal Chemistry +15

2,2-Difluoro-3-hydroxyesters by reformatskii reaction

E. Ann Hallinan, Josef Fried · Tetrahedron Letters · 1984 · 146 citations

Natural Sciences, Chemistry, Organic Chemistry +1

2'-fluoro-5-iodo-aracytosine, a potent and selective anti-herpesvirus agent

Carlos López, Kyoichi A. Watanabe, Jack J. Fox · Antimicrobial Agents and Chemotherapy · 1980 · 142 citations · Full text

Medicine, Infectious Diseases, Pharmacology +13