Removal of O6-methylguanine from DNA of normal and xeroderma pigmentosum-derived lymphoblastoid lines

Possible Relevance of O–6 Alkylation of Deoxyguanosine to the Mutagenicity and Carcinogenicity of Nitrosamines and Nitrosamides

A. Loveless · Nature · 1969 · 948 citations

Pharmacy, Pharmacology, Toxicology +14

Methylation of deoxyribonucleic acid in cultured mammalian cells by <i>N</i>-methyl-<i>N</i>′-nitro-<i>N</i>-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen atom of guanine as a site of methylation

P.D. Lawley, Carolyn J. Thatcher · Biochemical Journal · 1970 · 495 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +10

Persistence of <i>O</i> 6-Ethylguanine in Rat-Brain DNA: Correlation with Nervous System-Specific Carcinogenesis by Ethylnitrosourea

Regine Goth, Manfred F. Rajewsky · Proceedings of the National Academy of Sciences · 1974 · 490 citations · Full text

Medicine, Oncology, Toxicology +15

Two forms of repair in the DNA of human cells damaged by chemical carcinogens and mutagens.

James D. Regan, R. B. Setlow · PubMed · 1974 · 442 citations

Life Sciences, Molecular Biology, Dna Repair +12

All oxygens in nucleic acids react with carcinogenic ethylating agents

Brett C. Singer · Nature · 1976 · 310 citations

Pharmacy, Molecular Biology, Toxicology +11