Concepedia

Increased expression of cdk5/p25 in N2a cells leads to hyperphosphorylation and impaired axonal transport of neurofilament proteins

Jie Zhou, Hongxing Wang, Youmei Feng, Juan Chen

Life Sciences · 2010 · 27 citations · 33 references

DOI

Concepts

References

33

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Gentry N. Patrick, Lawrence Zukerberg, Margareta Nikolić et al. · Nature · 1999 · 1.5K citations

, , +10

Neurotoxicity induces cleavage of p35 to p25 by calpain

Ming‐Sum Lee, Young T. Kwon, Mingwei Li et al. · Nature · 2000 · 1.1K citations

, , +9

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

Margareta Nikolić, Henryk Dudek, Young T. Kwon et al. · Genes & Development · 1996 · 600 citations · Full text

, , +12

NUDEL Is a Novel Cdk5 Substrate that Associates with LIS1 and Cytoplasmic Dynein

Martin Niethammer, Deanna S. Smith, Ramsés Ayala et al. · Neuron · 2000 · 481 citations · Full text

, , +7

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity

Margareta Nikolić, Margaret M. Chou, Wange Lu et al. · Nature · 1998 · 402 citations

, , +6