Digestion · 2009 · 27 citations · 0 references
MedicineNutritionNutritional SciencesBioavailabilityIron Metabolism DisordersMineral MetabolismFood Effects On Oral AbsorptionGastrointestinal PharmacologyIntestinal Mineral AbsorptionIron DeficiencyIron NutritionMicronutrient AbsorptionAlginateDietary Inhibitors Of AbsorptionDietary Iron AbsorptionIntestinal Iron AbsorptionIntestinal Iron TransportIron Absorption InhibitionIron Absorption KineticsMineral Absorption Inhibitors
Na-alginate as well as guar gum inhibit the absorption of a 59Fe-labelled iron dose (360 nmol) from tied-off jejunal segments of either normal or iron-deficient rats. In order to inhibit the absorption of the iron dose by half as compared with normal rats to which ionized iron was administered 1.2--8 mg of guar gum and 8-30 mg Na-alginate was necessary. In iron-deficient rats the highest dose dose of Na-alginate tested, 100 mg, inhibited the absorption of iron by about 20%; the highest dose of guar gum, 30 mg, inhibited the amount of iron absorbed by about 25%. An artificial diet containing 10% of either guar gum and Na-alginate fed for 3 days inhibited the absorption of iron in normal but not in iron-deficient rats. Also, in these experiments guar gum proved to be more effective than Na-alginate.